منابع مشابه
Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution.
Development of the ancient innate immune system required not only a mechanism to recognize foreign organisms from self but also to destroy them. Pore-forming proteins containing the membrane attack complex Perforin domain were one of the first triumphs of an innate immune system needing to eliminate microbes and virally infected cells. Membrane attack complex of complement and Perforin domain p...
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Until around 1990, most multigene families were thought to be subject to concerted evolution, in which all member genes of a family evolve as a unit in concert. However, phylogenetic analysis of MHC and other immune system genes showed a quite different evolutionary pattern, and a new model called birth-and-death evolution was proposed. In this model, new genes are created by gene duplication a...
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A dense-enough gas-accumulation evolves, over a few Myr of intensifying star formation, to an embedded cluster. If it contains a sufficient amount of mass, O stars form and explosively expel the remaining gas, whereas poorer clusters reduce their embryonic gas content more gradually. The sudden expulsion of gas unbinds most of a rich cluster, but a significant fraction of it can condense by two...
متن کاملThe frequent evolutionary birth and death of functional promoters in mouse and human.
Promoters are central to the regulation of gene expression. Changes in gene regulation are thought to underlie much of the adaptive diversification between species and phenotypic variation within populations. In contrast to earlier work emphasizing the importance of enhancer evolution and subtle sequence changes at promoters, we show that dramatic changes such as the complete gain and loss (col...
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Moving the nucleus to a specific position within the cell is an important event during many cell and developmental processes. Several different molecular mechanisms exist to position nuclei in various cell types. In this Commentary, we review the recent progress made in elucidating mechanisms of nuclear migration in a variety of important developmental models. Genetic approaches to identify mut...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2020
ISSN: 1471-2148
DOI: 10.1186/s12862-020-01698-1